128. Lee SH, Chung KC. (2023) USP7 attenuates endoplasmic reticulum stress-induced apoptotic cell death through deubiquitination and stabilization of FBXO7. PLoS One. 18(10), e0290371

127. Lee SH, Lee YJ, Jung S, Chung KC. (2023) E3 ligase adaptor FBXO7 contributes to ubiquitination and proteasomal degradation of SIRT7 and promotes cell death in response to hydrogen peroxide. J. Biol. Chem. 102909


126. Lee YH, Suh BK, Lee U, Ryu SH, Shin SR, Chang S, Park SK, Chung KC. (2022) DYRK3 phosphorylates SNAPIN to regulate axonal retrograde transport and neurotransmitter release. Cell Death Discovery. 8, 503

125. Jeon SJ, Chung KC. (2022) Covalent conjugation of ubiquitin-like ISG15 to apoptosis inducing factor exacerbates toxic stimuli-induced apoptotic cell death. J. Biol. Chem. 298, 102464

124. Jang HJ, Chung KC. (2022) The ubiquitin-proteasome system and autophagy mutually interact in neurotoxin-induced dopaminergic cell death models of Parkinson’s disease. FEBS Lett. 596, 2896-2913

123. Shin WH, Chung KC. (2022) Tollip negatively regulates mitophagy by promoting the mitochondrial processing and cytoplasmic release of PINK1. BMB Rep. 55, 494-499


122. Park GH, Park JH, Chung KC. (2021) Precise control of mitophagy through ubiquitin proteasome system and deubiquitin proteases and their dysfunction in Parkinson’s disease. BMB Rep. 54, 592-600 (Invited Review)

121. Lee SH, Jung S, Lee YJ, Hyun M, Chung KC. (2021) FBXO7 triggers caspase 8-mediated proteolysis of the transcription factor FOXO4 and exacerbates neuronal cytotoxicity. J. Biol. Chem. 297, 101426

120. Lee YH, Im E, Hyun M, Park J, Chung KC. (2021) Protein phosphatase PPM1B inhibits DYRK1A through dephosphorylation of pS258 and reduces toxic tau aggregation. J. Biol Chem. 296, 100245


119. Shin WH, Chung KC. (2020) Death-associated protein kinase 1 phosphorylates α-synuclein at Ser129 and exacerbates rotenone-induced toxic aggregation of α-synuclein in dopaminergic SH-SY5Y cells. Exp. Neurobiol. 29, 207-218

118. Shin WH, Chung KC. (2020) Human telomerase reverse transcriptase positively regulates mitophagy by inhibiting the processing and cytoplasmic release of mitochondrial PINK1. Cell Death & Dis.11, 425

117. Chung KC. (2020) Mitochondria and Neurodegenerative Diseases: Special Issue of BMB Reports in 2020. BMB Rep. 53(1), 1-2 (Editorial)

116. Shin WH, Park JH, Chung KC. (2020) The central regulator p62 between ubiquitin proteasome system and autophagy and its role in the mitophagy and Parkinson’s disease. BMB Rep. 53(1), 56-63 (Invited Review)


115. Jo MG, Ikram M, Jo MH, Yoo L, Chung KC, Nah SY, Hwang H, Rhim H, Kim MO. (2019) Gintonin mitigates MPTP-induced loss of nigrostriatal dopaminergic neurons and accumulation of α-synuclein via the Nrf2/HO-1 pathway. Molecular Neurobiology 56, 39-55


114. Yoo L, Chung KC. (2018) The ubiquitin E3 ligase CHIP promotes proteasomal degradation of the serine/threonine protein kinase PINK1 during staurosporine-induced cell death. J. Biol. Chem. 293, 1286-1297

113. Min B, Chung KC. (2018) New insight into transglutaminase 2 and link to neurodegenerative diseases. BMB Rep. 51, 5-13 (Invited Review)

112. Yoo L, Yoon AR, Yun CO, Chung KC. (2018) Covalent ISG15 conjugation to CHIP promotes its ubiquitin E3 ligase activity and inhibits lung cancer cell growth in response to type I interferon. Cell Death & Dis. 9, 97


111. Han KA, Yoo L, Sung JY, Chung SA, Um JW, Kim H, Seol W, Chung KC. (2017) Leucine-rich repeat kinase 2 (LRRK2) stimulates IL-1β-mediated inflammatory signaling through phosphorylation of RCAN1. Front. Cell. Neurosci. 11, 125

110. Kim DY, Hong A, Park HI, Shin WH, Yoo L, Jeon SJ, Chung KC. (2017) Deubiquitinating enzyme USP22 positively regulates c-Myc stability and tumorigenic activity in mammalian and breast cancer cells. J. Cell. Physiol. 232, 3664-3676

109. Im E, Yoon JB, Lee HW, Chung KC. (2017) Human telomerase reverse transcriptase (hTERT) positively regulates 26S proteasome activity. J. Cell. Physiol. 232, 2083-2093

108. Han KA, Shin WH, Jung S, Seol W, Seo H, Ko C, Chung KC. (2017) LRRK2 exacerbates neuronal cytotoxicity through HDAC3 phosphorylation and histone deacetylation. Hum. Mol. Gen. 26, 1-18


107. Oakley OR, Kim KJ, Lin PC, Barakat R, Cacioppo JA, Li Z, Whitaker A, Chung KC, Mei W, Ko C. (2016) Estradiol synthesis in gut-associated lymphoid tissue: Leukocyte regulation by a sexually monomorphic system. Endocrinology 157, 4579-4587

106. Im E, Chung KC. (2016) Precise assembly and regulation of 26S proteasome and correlation between proteasome dysfunction and neurodegenerative diseases. BMB Reports 49, 459-473 (Invited review)

105. Im E, Yoo L, Hyun M, Shin WH, Chung KC. (2016) Covalent ISG15 conjugation positively regulates the ubiquitin E3 ligase activity of parkin. Open Biology 6, 160193

104. Hwang JY, Lee J, Oh CK, Kang HW, Hwang IY, Um JW, Park HC, Kim S, Shin JH, Park WY, Darnell RB, Um HD, Chung KC, Kim KJ, Oh YJ. (2016) Proteolytic degradation and potential role of onconeural protein cdr2 in neurodegeneration. Cell Death & Dis. 7, e2240

103. Min B, Park H, Lee S, Li Y, Choi JM, Lee JY, Kim J, Choi YD, Kwon YG, Lee HW, Bae SC, Yun CO, Chung KC. (2016) CHIP-mediated degradation of transglutaminase 2 negatively regulates tumor growth and angiogenesis in renal cancer. Oncogene 35, 3718-3728


102. Ho DH, Kim H, Kim J, Sim H, Ahn H, Kim J, Seo H, Chung KC, Park BJ, Son I, Seol W. (2015) Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21WAF1/CIP1 expression. Mol. Brain 8, 54

101. Im E, Chung KC. (2015) Dyrk1A phosphorylates parkin at Ser-131 and negatively regulates its ubiquitin E3 ligase activity. J. Neurochem. 134, 756-68

100. Hong A, Lee JE, Chung KC. (2015) Ubiquitin-specific protease 22 (USP22) positively regulates RCAN1 protein levels through RCAN1 de-ubiquitination. J. Cell Physiol. 230, 1651-1660

99. Min B, Kwon YC, Choe KM, Chung KC. (2015) PINK1 phosphorylates transglutaminase 2 and blocks its proteasomal degradation. J. Neurosci. Res. 95, 722-735

98. Kang J, Chung KC. (2015) The F-Box protein FBXO7 positively regulates bone morphogenetic protein-mediated signaling through Lys-63-specific ubiquitination of neurotrophin receptor-interacting MAGE (NRAGE). Cell. Mol. Life Sci. 72, 181-195


97. Ko JW, Lim SY, Chung KC. Lim JW, Kim H. (2014) Reactive oxygen species mediate IL-8 expression in Down syndrome candidate region-1-overexpressed cells. Int. J. Biochem. Cell Biol. 55, 164-170

96. Han KA, Kang HS, Lee JW, Yoo L, Im E, Hong A, Lee YJ, Shin WH, Chung KC. (2014) Histone deacetylase 3 promotes RCAN1 stability and nuclear translocation PLoS One 9(8):e105416

95. Kim SH, Kim DH, Lee KH, Im SK, Hur EM, Chung KC, Rhim H. (2014) Direct Interaction and Functional Coupling between Human 5-HT6 Receptor and the Light Chain 1 Subunit of the Microtubule-Associated Protein 1B (MAP1B-LC1). PLoS One 9(3), e91402


94. Park J, Chung KC. (2013) New perspectives of Dyrk1A role in neurogenesis and neuropathologic features of Down syndrome. Experimental Neurobiology 22, 244-248

93. Jung HJ, Kim YJ, Eggert S, Chung KC, Choi KS, Park SA (2013) Age-dependent increases in tau phosphorylation in the brains of type 2 diabetic rats correlate with a reduced expression of p62. Exp. Neurol. 248:441-50

92. Oh Y, Chung KC. (2013) UHRF2, an ubiquitin E3 ligase, acts as a small ubiquitin-like modifier E3 ligase for zinc finger protein 131. J. Biol. Chem. 288, 9102-9111

91. Oh Y, Chung KC. (2013) Zinc finger protein 131 inhibits estrogen signaling by suppressing estrogen receptor α homo-dimerization. Biochem. Biophy. Res. Commun. 430:400-405


90. Lee HJ, Chung KC. (2012) PINK1 positively regulates interleukin-1β-mediated signaling through Tollip and IRAK1 modulation. J. Neuroinflammation 9:271 [listed in a special interest to the drug development in LeadDiscovery's DailyUpdates service (http://www.leaddiscovery.co.uk/articles/23244239/dailyupdate/)]

89. Noh EH, Hwang HS, Hwang HS, Min B, Im E, Chung KC. (2012) Covalent NEDD8 conjugation increases RCAN1 protein stability and potentiates its inhibitory action on calcineurin. PLoS One 7, e48315

88. Lee HJ, Jang SH, Kim H, Yoon JH, Chung KC. (2012) PINK1 stimulates interleukin-1β-mediated inflammatory signaling via the positive regulation of TRAF6 and TAK1. Cell. Mol. Life Sci. 69, 3301-3315

87. Oh Y, Chung KC. (2012) Small ubiquitin-like modifier (SUMO) modification of zinc finger protein 131 potentiates its negative effect on estrogen signaling. J. Biol. Chem. 287, 17517-17529

86. Lee JW, Kang HS, Lee JY, Lee EJ, Rhim H, Yoon JH, Seo SR, Chung KC. (2012) The transcription factor STAT2 enhances proteasomal degradation of RCAN1 through the ubiquitin E3 ligase FBW7. Biochem. Biophy. Res. Commun. 420, 404-410

85. Kim SS, Oh Y, Chung KC, Seo SR. (2012) Protein kinase A phosphorylates Down Syndrome Critical Region 1 (RCAN1). Biochem. Biophy. Res. Commun. 418, 657-661

84. Um JW, Han KA, Im E, Oh Y, Lee K, Chung KC. (2012) Neddylation positively regulates the ubiquitin E3 ligase activity of parkin. J. Neurosci. Res. 90, 1030-1042 [selected as a special interest to the drug development sector and listed on Global Medical Discovery Series (http://globalmedicaldiscovery.com)] (http://globalmedicaldiscovery.com/key-scientific-articles/neddylation-positively-regulates-the-ubiquitin-e3-ligase-activity-of-parkin/)

83. Park J, Sung JY, Park J, Song WJ, Chang S, Chung KC. (2012) Dyrk1A negatively regulates the actin cytoskeleton through threonine phosphorylation of N-WASP. J. Cell Sci. 125, 67-80 [selected as feature article ‘In This Issue’ section of JCS’]

82. Min B, Kim MK, Zhang JW, Kim J, Chung KC, Oh BC, Stein GS, Lee YH, van Wijnen AJ, Bae SC. (2012) Identification of RUNX3 as a component of the MST/Hpo signaling pathway. J. Cell. Physiol. 227, 839-849


81. Kim YM, Jang WH, Quezado MM, Oh Y, Chung KC, Junn E, Mouradian MM. (2011) Proteasome inhibition induces α-synuclein SUMOylation and aggregate formation. J. Neurol. Sci. 307, 157-161

80. Choi HK, Chung KC. (2011) Dyrk1A positively stimulates ASK1-JNK signaling pathways during apoptotic cell death. Exp. Neurobiol. 20, 35-44

79. Oh Y, Kim YM, Mouradian MM, Chung KC. (2011) Human polycomb protein 2 promotes α-synuclein aggregate formation through covalent SUMOylation. Brain Res. 1381, 78-89


78. Kim DH, Kim SH, Kim HJ, Jin CB, Chung KC, Rhim H. (2010) Stilbene derivatives as human 5-HT(6) receptor antagonists from the root of Caragana sinica. Biol. Pharm. Bull. 33, 2024-2028

77. Um JW, Im E, Park J, Oh Y, Min B, Lee HJ, Yoon JB, Chung KC. (2010) ASK1 negatively regulates the 26S proteasome. J. Biol. Chem. 285, 36434-36446 (selected as Papers of the Week)

76. Park J, Oh Y, Yoo L, Jung MS, Song WJ, Lee SH, Seo H, Chung KC. (2010) Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. J. Biol. Chem. 285, 31895-31906

75. Um JW, Im E, Lee HJ, Min B, Yoo L, Yoo J, Lübbert H, Stichel-Gunkel G, Cho HS, Yoon JB, Chung KC. (2010) Parkin Directly modulates 26S Proteasome Activity. J. Neurosci. 30, 11805-11814 (selected as a Faculty of 1000 Biology Evaluated Article)

74.Um JW, Park HJ, Song J, Jeon I, Lee G, Lee PH, Chung KC. (2010) Formation of parkin aggregates and enhanced PINK1 accumulation during the pathogenesis of Parkinson's disease. Biochem. Biophys. Res. Commun. 393, 824-828


73. Seo SR, Kim SS, Chung KC. (2009) Activation of adenylate cyclase by forskolin increases the protein stability of RCAN1 (DSCR1 or Adapt78). FEBS Lett. 583, 3140-3144

72. Lee JY, Lee HJ, Lee EJ, Jang SH, Kim H, Yoon JH, Chung KC. (2009) Down syndrome candidate region-1 protein interacts with Tollip and positively modulates interleukin-1 receptor-mediated signaling. Biochim. Biophys. Acta - General Subjects 1790, 1673-1680

71. Park J, Song WJ, Chung KC. (2009) Function and regulation of Dyrk1A: Towards understanding Down syndrome. Cell. Mol. Life Sci. 66, 3235-3240 (Invited review)

70. Park HM. Kim GY, Nam MK, Seong GH, Han C. Chung KC, Kang S, Rhim H. (2009) The serine protease HtrA2/Omi cleaves Parkin and irreversibly inactivates its E3 ubiquitin ligase activity. Biochem. Biophys. Res. Commun. 387, 537-542

69. Park JY, Kim KS, Lee SB, Chung KC, Jou I, Kim J, Park SM. (2009) On the mechanism of internalization of α-synuclein into microglia: Roles of ganglioside GM1 and lipid-raft.  J. Neurochem. 110, 400-411

68. Lee S, Park SM, Ahn KJ, Chung KC, Paik SR, Kim J. (2009) ldentification of the amino acid sequence motif of α-synuclein responsible for macrophage activation. Biochem. Res. Commun. 381, 39-43

67. Park J, Oh Y, Chung KC. (2009) Two key genes closely implicated with the neuropathological characteristics in Down syndrome: DYRK1A and RCAN1. BMB Reports 42, 6-15 (Invited review)

66. Um JW, Stichel-Gunkel, Lübbert H, Lee G, Chung KC. (2009) Molecular interaction between parkin and PINK1 in mammalian neuronal cells. Mol. Cell. Neurosci. 40, 421-432

65. Kim T, Kim S, Yun HM, Chung KC, Han YS, Shin HS, Rhim H. (2009) Modulation of Ca(v)3.1 T-type Ca2+ channels by the Ran binding protein RanBPM. Biochem. Biophys. Res. Commun. 378, 15-20


64. Song KS, Kim K, Chung KC, Seol JH, Yoon JH. (2008) Interaction of SOCS3 with NonO attenuates IL-1β-dependent MUC8 gene expression Biochem. Biophys. Res. Commun. 377, 946-951

63. Cha SS, Jung HI, Jeon H, An YJ, Kim IK, Yun S, Ahn HJ, Chung KC, Lee SH, Suh PG, Kang SO. (2008) Crystal structure of filamentous aggregates of human DJ-1 formed in an inorganic phosphate-dependent manner. J. Biol. Chem. 283, 34069-34075

62. Song HJ, Park J, Seo SR, Kim J, Paik SR, Chung KC. (2008) Down syndrome critical region 2 protein inhibits the transcriptional activity of peroxisome proliferator-activated receptor β in HEK293 cells. Biochem. Biophys. Res. Commun. 376, 478-482

61. Song KS, Lee TJ, Kim K, Chung KC, Yoon JH. (2008) CREB and c-Ets1 interact in the regulation of ATP-dependent MUC5AC gene expression. J. Biol. Chem. 283, 26869-26878

60. Park JW, Lee IH, Hahn JS, Kim J, Chung KC, Paik SR. (2008) Disintegration of amyloid fibrils of α-synuclein by dequalinium. Biochim. Biophys. Acta - General Subjects. 1780, 1156-1161

59. Seo SR, Chung KC. (2008) CREB activates proteasomal degradation of DSCR1/ RCAN1. FEBS Lett. 582, 1889-1893

58. Oh DY, Cho JH, Park SY, Kim YS, Yoon SH, Chung KC, Lee KS, Han JS. (2008) A novel role of hippocalcin in bFGF-induced neurite outgrowth of H19-7 cells, J. Neurosci. Res. 86, 1557-1565

57. Lee EJ, Seo SR, Um JW, Park J, Oh Y, Chung KC. (2008) NF-kappaB-inducing kinase phosphorylates and blocks the degradation of DSCR1. J. Biol. Chem. 283, 3392-3400

56. Ryu V, Lee JH, Urn JW, Yoo SB, Lee J, Chung KC, Jahng JW. (2008) Water-deprivation-induced expression of neuronal nitric oxide synthase in the hypothalamic paraventricular nucleus of rat. J. Neurosci. Res. 86, 1371-1379


55. Kim S, Yun HM, Baik JH, Chung KC, Nah SY, Rhim H. (2007) Functional interaction of neuronal Cav1.3 L-type calcium channel with ryanodine receptor type2 in the rat hippocampus. J. Biol. Chem. 282, 32877-32889

54. Park J, Yang EJ, Yoon JH, Chung KC. (2007) Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of Down syndrome. Mol. CelI. Neurosci. 36, 270-279

53. Lee EJ, Lee JY, Seo SR, Chung KC. (2007) Overexpression of DSCR1 blocks zinc-induced neuronal cell death through the formation of nuclear aggregates. Mol. Cell. Neurosci. 35, 585-595

52. Jin JK, Ahn BH, Na YJ, Kim JI, Kim YS, Choi EK, Ko YG, Chung KC, Kozlowski PB, Min DS. (2007) Phospholipase D1 is associated with amyloid precursor protein in Alzheimer's disease. Neurobiology of Aging 28, 1015-1027

51. Sung JY, Lee HJ, Jeong EI, Oh Y, Park J, Kang KS, Chung KC. (2007) α-Synuclein overexpression reduces gap junctional intercellular communication in dopaminergic neuroblastoma cells. Neurosci. Lett. 416, 289-293

50. Min YK, Lee JE, Chung KC. (2007) Zinc induces cell death in immortalized embryonic hippocampal cells via activation of Akt-GSK-3β Signaling. Exp. Cell Res. 313, 312-321

49. Park JB, Kim EJ, Yang EJ, Seo SR, Chung KC. (2007) JNK- and Rac1-dependent induction of immediate early gene pip92 suppresses neuronal differentiation. J. Neurochem. 100, 555-566


48.Kim SJ, Kim SY, Na YS, Lee HJ, Chung KC, Baik JH. (2006) α-Synuclein enhances dopamine D2 receptor signaling. Brain Res. 1124, 5-9

47. Kim EJ, Sung JY, Lee HJ, Rhim H, Hasegawa M, Iwatsubo T, Min DS. Kim J, Paik SR, Chung KC. (2006) Dyrk1A phosphorylates α-synuclein and enhances intracellular inclusion formation. J. Biol. Chem. 281, 33250-33257

46. Choi SA, Kim SJ, Chung KC. (2006) Huntingtin-interacting protein 1-mediated neuronal cell death occurs through intrinsic apoptotic pathways and mitochondrial alterations. FEBS Lett. 580, 5275-5282

45. Kim HJ, Lee D, Lee CH, Chung KC, Kim J, Paik SR. (2006) Calpain-resistant fragment(s) of α-synuclein regulates the synuclein-cleaving activity of 20S proteasome. Arch. Biochem. Biophys. 455, 40-47

44. Um JW, Chung KC. (2006) Functional modulation of parkin through physical interaction with SUMO-1. J. Neurosci. Res. 84, 1543-1554

43. Lee E, Kim S, Chung KC, Choo MK, Kim DH, Nam G, Rhim H. (2006) 20(S)-ginsenoside Rh2, a newly identified active ingredient of ginseng, inhibits NMDA receptors in cultured rat hippocampal neurons. Eur. J. Pharm. 536(1-2), 69-77

42. Ahn KJ, Paik SR, Chung KC, Kim J. (2006) Amino acid sequence motifs and mechanistic features of the membrane translocation of α-synuclein. J. Neurochem. 97, 265-279

41. Park KS, Jeon SH, Kim SE, Bahk YY, Holmen SL, Williams BO, Chung KC, Surh YJ, Choi KY. (2006) APC inhibits ERK pathway activation and cellular proliferation induced by RAS. J. Cell Sci. 119, 819-827

40. Lee CH, Kim HJ, Lee JH, Cho HJ, Kim J, Chung KC, Jung S, Paik SR. (2006) Dequalinium-induced protofibril formation of α-synuclein. J. Biol. Chem. 281, 3463-3472

39. Um JW, Min DS, Rhim H, Kim J, Paik SR, Chung KC. (2006) Parkin ubiquitinates and promotes the degradation of RanBP2. J. Biol. Chem. 281, 3595-3603

38. Kim J, Lee YH, Kwon TK, Chang JS, Chung KC, Min DS. (2006) Phospholipase D prevents etoposide-induced apoptosis by inhibiting the expression of early growth response­-1 and phosphatase and tensin homologue deleted on chromosome 10. Cancer Res. 66, 784-793


37. Sung JY, Park SM, Lee CH, Um JW, Lee HJ, Kim J, Oh J, Lee ST, Paik SR, Chung KC. (2005) Proteolytic cleavage of extracellular secreted α-synuclein via matrix metalloproteinases. J. Biol. Chem. 280, 25216-25224

36. Kang JE, Choi SA, Park JB, Chung KC. (2005) Regulation of the proapoptotic activity of huntingtin interacting protein 1 by Dyrk1 and caspase-3 in hippocampal neuroprogenitor cells. J. Neurosci. Res. 81, 62-72

35. Cho KN, Choi JY, Kim CH, Baek SJ, Chung KC, Moon UY, Kim KS, Lee WJ, Koo JS, Yoon JH. (2005) Prostaglandin E2 induces MUC8 gene expression via a mechanism involving ERK MAPK/RSK1/cAMP response element binding protein activation in human airway epithelial cells. J. Biol. Chem. 280, 6676-6681


34. Kim SM, Park JH, Chung SK, Kim JY, Hwang HY, Chung KC, Jo I, Park SI, Nam JH. (2004) Coxsackievirus B3 infection induces cyr61 activation via JNK to mediate cell death. J. Virology. 78, 13479-13488

33. Kim I, Kim CH, Kim JH, Lee J, Choi JJ, Chen ZA, Lee MG, Chung KC, Hsu CY, Ahn YS. (2004) Pyrrolidine dithiocarbamate and zinc inhibit proteasome-dependent proteolysis. Exp. Cell Res. 298, 229-238

32. Lee EN, Cho HJ, Lec CH, Lee D, Chung KC, Paik SR. (2004) Phthalocyanine tetrasulfonates affect the amyloid formation and cytotoxicity of α-synuclein. Biochemistry 43, 3704-3715

31. Yang EJ, Yoon JH, Min DS, Chung KC. (2004) LIM kinase 1 activates cAMP-responsive element-binding protein during the neuronal differentiation of immortalized hippocampal progenitor cells. J. Biol. Chem. 279, 8903-8910

30. Yang EJ, Yoon JH, Chung KC. (2004) Bruton's tyrosine kinase phosphorylates CREB at Ser-133 during neuronal differentiation in immortalized hippocampal progenitor cells. J. Biol. Chem. 279, 1827-1837


29. Lee YM, Park SH, Chung KC, Oh YJ. (2003) Proteomic analysis reveals upregulation of calreticulin in depaminergic neuronal cells after treatment with 6-hydroxydopamine. Neurosci. Lett. 352, 17-20

28. Kim SJ, Sung JY, Um JW, Hattori H, Mizuno Y, Tanaka K, Paik SR, Kim J, Chung KC. (2003) Parkin cleaves intracellular α-synuclein inclusions via the activation of calpain. J. Biol. Chem. 278, 41890-41899

27. Han J S, Macarak E, Rosenbloorn J, Chung KC, Chaqour B. (2003) Regulation of Cyr61/CCN1 gene expression through RhoA GTPase and p38 MAPK signaling pathways: Role of CREB and AP-1 transcription factors. Eur. J. Biochem. 270, 3408-3421

26. Song KS, Seong JK, Chung KC, Lee WJ, Cho KN, Kang CD, Koo JS, Yoon JH. (2003) Induction of MUC8 gene expression by interleukin-1β is mediated by a sequential ERK MAP kinase/RSK1/CREB cascade pathway in human airway epithelial cells. J. Biol. Chem. 278, 34890-34896

25. Song KS, Lee WJ, Chung KC, Koo JS, Yang EJ, Choi JY, Yoon JH. (2003) Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells. J. Biol. Chem. 278, 23243-23250

24. Kim KH, Min YK, Baik JH, Lau LF, Chaqour B, Chung KC. (2003) Expression of angiogenic factor Cyr61 during neuronal cell death via the activation of c-Jun N-terminal kinase and serum response factor. J. Biol. Chem. 278, 13847-13854

23. Min YK, Park JH, Chong SA, Kim YS, Ahn YS, Seo JT, Bae YS, Chung KC. (2003) Pyrrolidine dithiocarbamate-induced neuronal cell death is mediated by Akt, casein kinase 2, c-Jun N-terminal kinase, and IκB kinase in embryonic hippocampal progenitor cells. J. Neurosci. Res. 71, 689-700


22. Park SM, Jung HY, Chung KC, Rhim H, Park JH, Kim J. (2002) Stress-induced aggregation profiles of GST-α-Synuclein fusion proteins: Role of the C-­terminal acidic tail of α-Synuclein in protein thermosolubility and stability. Biochemistry 41, 4137-4146

21. Ahn BH, Rhim H, Kiln SY, Sung YM, Lee MY, Choi JY, Wolozin B, Chang JS, Kwon TK, Chung KC, Rhie DJ, Yoon SH, Hahn SJ, Kim MS, Min DS. (2002) α-Synuclein interacts with phospholipase D isozymes and inhibits pervanadate-induced phospholipase D activation in human embryonic kidney 293-cells. J. Biol. Chem. 277, 12334-12342

20. Park SM, Jung HY, Kim HO, Rhim H, Paik SR, Chung KC, Park JH, Kim J. (2002) Evidence that α-synuclein functions as a negative regulator of Ca2+-dependent α-granule release from human platelets. Blood 100, 2506-2514


19. Yang EJ, Ahn YS, Chung KC. (2001) Protein kinase Dyrk1 activates CREB protein during neuronal differentiation in CNS hippocampal progenitor cells. J. Biol. Chem. 276, 39819-39824

18. Sung JY, Kim J, Paik SR, Park JH, Ahn YS, Chung KC. (2001) Induction of neuronal cell death by Rab5A-dependent endocytosis of α-synuclein. J. Biol. Chem. 276, 27441-27448

17. Seo SR, Chong SA, Lee SI, Sung JY, Ahn YS, Chung KC, Seo JT. (2001) Zn2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells. J. Neurochem. 78, 600-610

16. Sung JY, Lee SY, Min DS, Eom TY, Ahn YS, Choi MU, Kwon YK, Chung KC. (2001) Differential activation of phospholipases by mitogenic EGF and neurogenic PDGF in immortalized hippocampal stem cell lines. J. Neurochem. 78, 1044-1053

15. Kim YS, Lee DY, Lee EK, Sung JY, Chung KC, Kim J, Paik SR. (2001) Multiple ligand interaction of α-synuclein produced various forms of protein aggregates in the presence of copper, and eosin. Brain Res. 908, 93-98

14. Sung JY, Shin SW, Ahn YS, Chung KC. (2001) Basic fibroblast growth factor-­induced activation of novel CREB kinase during the differentiation of immortalized hippocampal cells. J. Biol. Chem. 276, 13858-13866

13. Chung KC, Sung JY, Ahn W, Rhim H, Oh TH, Lee MG, Ahn YS. (2001) Intracellular calcium mobilization induces immediate early gene pip92 via Src and mitogen-activated protein kinase in immortalized hippocampal cells. J. Biol. Chem. 276, 2132-2138


12. Chung KC, Kim SM, Rhang S, Lau LF, Gomes I, Ahn YS. (2000) Expression of immediate early gene pip92 during anisomycin-induced cell death is mediated by the JNK- and p38-dependent activation of Elk1. Eur. J. Biochem. 267, 4676-4684

11. Chung KC, Shin SW, Yoo M, Lee MY, Lee HW, Choe BK, Ahn YS. (2000) A systemic administration of NMDA induces immediate early gene pip92 in the hippocampus. J. Neurochem. 75, 9-17

10. Chung KC, Park JH, Kim CH, Lee HW. Sato N, Uchiyama Y, Ahn YS. (2000) Novel biphasic effect of pyrrolidine dithiocarbamate on neuronal cell viability is mediated by the differential regulation of intracellular zinc and copper ion levels, NF-kappaB, and MAP kinases. J. Neurosci. Res. 59, 117-125


9. Kim CH, Kim JH, Moon SJ, Chung KC, Hsu CY, Seo JT, Ahn YS. (1999) Pyrithione, a zinc ionophore, inhibits NF-kappaB activation. Biochem. Biophys. Res. Comm. 259, 505-509

8.Chung KC, Park JH, Kim CH, Ahn YS. (1999) Tumor necrosis factor-alpha and phorbol 12-myristate 13-acetate differentially modulate cytotoxic effect of nitric oxide generated by serum deprivation in neuronal PC12 cells. J. Neurochem. 72, 1482-1488


7. Chung KC, Ahn YS. (1998) Expression of immediate early gene cyr61 during the differentiation of immortalized embryonic hippocampal neuronal cells. Neurosci. Lett. 255, 155-158

6. Chung KC, Gomes I, Wang D, Lau LF, Rosner MR. (1998) Raf and fibroblast growth factor phosphorylate Elk1 and activate the serum response element of the immediate early gene pip92 by mitogen-activated protein kinase-independent as well as -dependent signaling pathways. Mol. Cell. Biol. 18, 2272-2281


5. Kuo WL, Chung KC, Rosner MR. (1997) Differentiation of central nervous system neuronal cells by fibroblast-derived growth factor requires at least two signaling pathways: roles for Ras and Src. Mol. Cell. Biol. 17, 4633-4643


4. Morrison P, Chung KC, Rosner MR. (1996) Mutation of Di-leucine residues in the juxtamembrane region alters EGF receptor expression. Biochemistry 35, 14618-14624


3. Chung KC, Huang D, Chen A, Short S, Short ML, Zhang Z, Jungmann RA. (1995) Identification of a silencer module which selectively represses cyclic AMP-responsive element-dependent gene expression. Mol. Cell. Biol. 15, 6139-6149


2. Short ML, Huang D, Milkowski D, Short S, Kunstman K, Soong CJ, Chung KC, Jungmann RA. (1994) Analysis of the rat lactate dehydrogenase A subunit gene promoter/regulatory region. Biochem. J. 304, 391-398


1. Chung KC, Yu BS, Choi MU. (1990) Identification and characterization of phospholipid methyltransferases in rat brain myelin. Kor. Biochem. J. 23, 103-109